Jens J Holst Selected Research

Total Parenteral Nutrition

5/2017	Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition.
5/2014	Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
1/2012	Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs.
12/2010	Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure.
10/2008	The effects of variations in dose and method of administration on glucagon like peptide-2 activity in the rat.
12/2007	Glucagon-like peptide 2 has limited efficacy to increase nutrient absorption in fetal and preterm pigs.
6/2004	Onset of small intestinal atrophy is associated with reduced intestinal blood flow in TPN-fed neonatal piglets.

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Jens J Holst Research Topics

Disease

209	Type 2 Diabetes Mellitus (MODY) 10/2022 - 01/2002
80	Insulin Resistance 04/2022 - 03/2002
65	Obesity 11/2022 - 01/2002
47	Body Weight (Weight, Body) 01/2022 - 05/2003
43	Weight Loss (Weight Reduction) 04/2022 - 01/2007
40	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 03/2002
36	Hyperglycemia 01/2022 - 08/2006
26	Overweight 05/2022 - 03/2003
26	Glucose Intolerance 03/2022 - 09/2004
26	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 06/2007
16	Inflammation (Inflammations) 11/2022 - 03/2004
15	Bone Resorption 01/2022 - 12/2003
14	Short Bowel Syndrome 01/2019 - 07/2004
11	Non-alcoholic Fatty Liver Disease 01/2022 - 04/2016
10	Weight Gain 01/2017 - 10/2004
9	Cardiovascular Diseases (Cardiovascular Disease) 05/2021 - 07/2009
9	Chronic Kidney Failure (Chronic Renal Failure) 01/2020 - 01/2013
9	Hyperinsulinism (Hyperinsulinemia) 01/2020 - 03/2002
9	Hyperlipidemias (Hyperlipidemia) 01/2020 - 03/2003
8	Dyslipidemias (Dyslipidemia) 01/2022 - 01/2010
8	Metabolic Diseases (Metabolic Disease) 01/2022 - 10/2015
8	Chronic Pancreatitis 10/2017 - 09/2003
8	Atrophy 05/2017 - 06/2004
7	Prediabetic State (Prediabetes) 01/2021 - 05/2015
6	Nausea 01/2021 - 11/2005
5	Morbid Obesity 01/2020 - 11/2003
5	Hyperplasia 01/2018 - 04/2003
5	Intestinal Failure 05/2017 - 11/2006
4	Long QT Syndrome 10/2021 - 01/2017
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 10/2017
4	Gestational Diabetes (Gestational Diabetes Mellitus) 10/2020 - 10/2013
4	Schizophrenia (Dementia Praecox) 08/2019 - 01/2017
4	Glucagonoma 07/2019 - 01/2015
4	Liver Diseases (Liver Disease) 07/2019 - 01/2012
4	Neoplasms (Cancer) 07/2019 - 11/2016

Drug/Important Bio-Agent (IBA)

216	Glucose (Dextrose)FDA LinkGeneric 10/2022 - 03/2002
144	Glucagon-Like Peptide 1 (GLP 1)IBA 10/2022 - 01/2002
105	Glucagon (Glukagon)FDA Link 01/2022 - 03/2002
101	Insulin (Novolin)FDA Link 10/2022 - 03/2002
81	Hormones (Hormone)IBA 10/2022 - 03/2002
76	IncretinsIBA 01/2022 - 01/2002
45	Peptides (Polypeptides)IBA 10/2022 - 08/2002
26	Proteins (Proteins, Gene)FDA Link 12/2021 - 06/2004
25	Glucagon-Like Peptide-1 ReceptorIBA 01/2022 - 08/2009
19	CarbohydratesIBA 01/2022 - 03/2003
18	C-PeptideIBA 01/2022 - 05/2003
18	Metformin (Glucophage)FDA LinkGeneric 01/2022 - 01/2006
16	Triglycerides (Triacylglycerol)IBA 05/2022 - 03/2003
15	Dipeptidyl-Peptidase IV InhibitorsIBA 10/2022 - 01/2006
15	Hypoglycemic Agents (Hypoglycemics)IBA 01/2022 - 09/2004
15	Liraglutide FDA Link 01/2021 - 01/2013
14	Blood Glucose (Blood Sugar)IBA 01/2022 - 03/2004
14	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 01/2022 - 01/2002
12	Amino Acids FDA Link 01/2022 - 04/2007
12	LipidsIBA 01/2021 - 01/2004
10	Collagen Type I (Type I Collagen)IBA 01/2022 - 12/2003
10	Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA 11/2020 - 05/2002
10	Glucagon-Like Peptide-1 Receptor AgonistsIBA 01/2020 - 01/2008
9	Glucagon-Like Peptides (Enteroglucagon)IBA 05/2022 - 12/2003
9	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 03/2003
8	Sitagliptin Phosphate (Januvia)FDA Link 10/2022 - 11/2006
8	Glucagon Receptors (Glucagon Receptor)IBA 01/2022 - 01/2016
8	Pharmaceutical PreparationsIBA 01/2022 - 01/2002
8	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021 - 03/2004
8	Bile Acids and Salts (Bile Acids)IBA 01/2020 - 09/2009
8	EnzymesIBA 01/2018 - 11/2003
8	VildagliptinIBA 11/2016 - 01/2007
7	gastric inhibitory polypeptide receptorIBA 01/2022 - 01/2002
7	Glucagon-Like Peptide 2IBA 01/2019 - 11/2006
6	Exenatide (Byetta)FDA Link 01/2022 - 11/2005
6	LinagliptinIBA 01/2022 - 01/2010
6	Antipsychotic Agents (Antipsychotics)IBA 08/2019 - 01/2010
6	Peptide YYIBA 01/2019 - 02/2005
6	Gastrointestinal Hormones (Hormones, Gastrointestinal)IBA 05/2018 - 12/2003
5	Biomarkers (Surrogate Marker)IBA 11/2022 - 08/2008
5	LeptinIBA 10/2022 - 01/2008
5	GhrelinIBA 10/2022 - 01/2008
5	Nonesterified Fatty Acids (NEFA)IBA 03/2022 - 06/2003
5	C-Reactive ProteinIBA 01/2022 - 03/2004
5	Whey ProteinsIBA 01/2021 - 07/2009
5	Glutamine (L-Glutamine)FDA Link 01/2018 - 01/2009
5	Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA 11/2016 - 01/2008
5	Arginine (L-Arginine)FDA Link 04/2013 - 05/2010
4	glimepiride (Amarel)FDA LinkGeneric 01/2022 - 07/2014
4	Dietary Carbohydrates (Carbohydrate, Dietary)IBA 01/2022 - 09/2018
4	CollagenIBA 05/2021 - 08/2015
4	ProcollagenIBA 01/2021 - 08/2015
4	Alanine (L-Alanine)FDA Link 01/2021 - 01/2018

Therapy/Procedure

37	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2022 - 02/2009
32	Therapeutics 04/2022 - 09/2003
12	Glycemic Control 10/2022 - 08/2007
8	Intravenous Infusions 01/2022 - 12/2003
7	Parenteral Nutrition 11/2017 - 06/2004
7	Total Parenteral Nutrition 05/2017 - 06/2004
6	Caloric Restriction 01/2022 - 02/2010
6	High-Protein Diet 01/2022 - 01/2018
5	Subcutaneous Injections 01/2022 - 09/2003
5	Gastrectomy 01/2021 - 07/2007
4	Aftercare (After-Treatment) 01/2022 - 07/2007
4	Bariatric Surgery 05/2021 - 02/2014